Lipid nanoparticles (LNPs) are novel spherical vesicles with core-shell nanostructure. A typical LNP usually has a specially designed ionizable lipid component, which is positively charged at low pH (for RNA complexation) and neutral at physiological pH (reducing potential toxic effects compared with cationic liposomes). Due to their special characteristics and small size (~100 nm), LNPs could be uptake by cells via endocytosis and then release the cargo into the cytoplasm by low pH mediated endosomal escape. Thus, the LNPs possess additional advantages over the traditional lipid-based carriers such as improved nucleic acid encapsulation and transfection efficiency, better penetration capacity, and decreased cytotoxicity.
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jesigeo min about 1 year ago
Lipid nanoparticles (LNPs) offer an innovative approach to drug delivery. Their unique ionizable lipid component, which adapts to pH changes, enhances nucleic acid encapsulation and transfection efficiency while reducing toxicity. LNPs' small size enables cellular uptake and endosomal escape, cheap real diamond rings online making them promising carriers for improved drug delivery and therapeutic outcomes.
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