Lipid nanoparticles (LNPs) are novel spherical vesicles with core-shell nanostructure. A typical LNP usually has a specially designed ionizable lipid component, which is positively charged at low pH (for RNA complexation) and neutral at physiological pH (reducing potential toxic effects compared with cationic liposomes). Due to their special characteristics and small size (~100 nm), LNPs could be uptake by cells via endocytosis and then release the cargo into the cytoplasm by low pH mediated endosomal escape. Thus, the LNPs possess additional advantages over the traditional lipid-based carriers such as improved nucleic acid encapsulation and transfection efficiency, better penetration capacity, and decreased cytotoxicity.
Creative Biolabs has more than ten years of experience in developing liposomal formulations. We integrate the knowledge of well-known liposome academics into our liposome technology. Our team of liposome experts and support staff has successfully served thousands of customers all over the world. At Creative Biolabs, we provide a full set of liposomes custom services, we also offer various liposome analysis services to characterize liposome-based product and measure the embedding efficiency. We believe our best liposome products and services will meet the highest standards.
Introduction of Fatty Acids (FAs) are carboxylic acids with a long aliphatic chain, either saturated or unsaturated. FA vesicles are colloidal suspensions of closed lipid bilayers, which are composed of fatty acids and their ionized species (soap). They are observed in a small region within the fatty acid-soap-water ternary phase diagram above the chain melting temperature (Tm) of the corresponding fatty acid-soap mixture.
Formulation Stability Monitoring Service at Creative Biolabs: Integrated with other advanced platforms, Creative Biolabs provides the most comprehensive products and services including liposome stability analysis. Physical, chemical and microbiological parameters must be considered and evaluated when designing stability studies.
Introduction to iPSC Research Methods: The iPSC technology is undoubtedly the most outstanding achievement made by the Stem Cell Research Institute, so it was selected as the top scientific and technological breakthrough in 2009. Unlike classic embryonic stem cell technology and somatic cell nuclear transfer technology, iPSC technology does not use embryonic cells or egg cells, avoiding ethical disputes. Moreover, the patient can use iPSC derived from autologous cells, thus avoiding immune rejection. In all, iPSC technology is greatly promising for clinical cell therapy.
mesenchymal stem cell research: Mesenchymal stem cells (MSC) have received significant attention in recent years with regard to their suitability for use in cellular therapies due to their high growth potential and multipotential differentiation capacity. As a trusted research partner in the field of biotherapeutics, Creative Biolabs provides cutting-edge cell therapy research services covering every stage of MSC development, including isolation, expansion, characterization, and differentiation.
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It is worth noticing that the fluorophore molecules conjugated to a given antibody should be similar in primary and isotype control antibodies. However, these fluorophore could be varied because of different manufacturers. Therefore, it is recommended to purchase both primary antibody and isotype control from the same supplier as far as possible.
Our antibody engineering team provides independent, custom service packages including antibody reformatting and production, epitope binning and mapping, antibody humanization, affinity maturation, affinity measurement, sequence liability identification, immunogenicity prediction, therapeutic developability assessment, and many other antibody specialization and modification services.
Anti-SARS-CoV antibodies: Severe acute respiratory syndrome (SARS), caused by SARS coronavirus (SARS-CoV), is a kind of respiratory viral diseases. It was first reported in 2003. Currently, there is no reported SARS transmission in the world. However, another kind of coronavirus, SARS-CoV-2 caused COVID-19 has become a pandemic since last December, 2019. COVID-19 showed many similarities to the previous SARS outbreak. Now worldwide scientists are dedicated to exploring mechanisms of SARS-CoV-2 and developing novel therapies to control this pandemic.