X-ray crystallography is currently the most favored method for structural determination of proteins and other macromolecules. The requisite for a successful X-ray crystallographic application is to obtain single crystals of the target protein. Data is then collected by diffracting X-ray from the single crystal that has an ordered pattern of atomic orientation. The assembly of atoms and molecules in the crystal can be deduced from the measurement of X-ray scattering.
At present, more than 120,000 protein structures resolved by X-ray crystallography experiments have been deposited in protein databank, accounting for nearly 90% of the resolved proteins, suggesting the predominant popularity of X-ray crystallography in structural determination.
Creative Biostructure provides X-ray crystallography services in our state-of-the-art facilities and has developed an X-ray crystallography pipeline that covers all technical stages from gene synthesis to structure determination. Our experienced scientists work closely with the clients to ensure rapid turnaround and reliable results.
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