The technology of induced pluripotent stem cell (iPSC) lines generation provides a valuable resource for disease modeling, regenerative therapy, and development study. However, the accumulation of karyotypic during long-term iPSCs culture results in chromosomal abnormalities, changes in gene expression and cellular functions, and even increases the risk of the iPSCs being tumorigenic. As genomic alterations present potential risks in the iPSCs applications, it is important to monitor the genomic integrity of these iPSCs lines especially in iPSCs intended for therapeutic use. Now Creative Biolabs has developed various strategies for the iPSC karyotype analysis. iPSC karyotype analysis is the examination of morphology. Moreover, the changes in size, the position of centromeres, and banding patterns are also necessary for detection aspects. Learn more: stem cell karyotype
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theki xe 15 days ago
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