In the recent years, more and more attention has been paid to investigate the roles of exosomes in therapeutic and diagnostic applications. Exosome labeling is a novel strategy for monitoring exosomes trafficking in vivo, which contributes to optimizing exosome-based diagnosis and treatment. With years of experiences in exosome labeling, Creative Biolabs has developed fluorescent labeling and biotin labeling techniques to track the distribution and movement of the specific exosomes.